B lactis HN019™ has been consumed in dairy foods for decades and is well-studied for its probiotic properties in more than 100 scientific publications. It has been demonstrated to tolerate acidic conditions and shown to survive passage through the human intestine.1-3 Mechanistic data suggests HN019™ may influence colonic motility, and multiple clinical trials with HN019™ alone or in combination with prebiotics or other probiotic strains have resulted in increased gut transit in persons with less frequent bowel movements.4-6 HN019™ has also been shown to modulate immune function, particularly enhancing cellular immune activity in aging persons.7
BIFIDOBACTERIUM LACTIS
HN019™
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HN019™ introduction
62 In vitro through product functionality studies
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Clinical trials
| HEALTH-BENEFIT AREA | SUPPORTED DOSING (CFU) | STUDY REFERENCE |
| Digestive health (gut regularity and occasional constipation) | 2 billion to 17 billion HN019™/day | Waller PA, et al. Scand J Gastroenterol. 2011;46(9):1057-1064. |
| Immune function in elderly adults | 5 billion minimum HN019™/day | Miller LE, et al. Nutrients. 2017; 9(3):191. |
For additional information, visit our HN019™ bibliography
REFERENCES:
1. Gopal PK, Prasad J, Gill HS Effects of the consumption of Bifidobacterium lactis HN019 (DR10 TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutrition Research. 2003;23:1313-1328. 2. Prasad J, Sazawal S, Dhingra U, Gopal PK Detection of viable Bifidobacterium lactis HN019 (DR10TM) in stools of children during a synbiotic dietary intervention trial. Intl Dairy J. 2013;30:64-67. 3. Wickens K, Black PN, Stanley TV, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clinical Immunology. 2008;122:788-794. 4. Dalziel JE, Anderson RC, Peters JS, et al. Promotility action of the probiotic Bifidobacterium lactis HN019 extract compared with prucalopride in isolated rat large intestine. Frontiers in Neuroscience. 2017; 11. 5. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled and dose-ranging trial. Gut Microbes. 2017; Dec 11:0. 6. Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scandinavian J Gastroenterology. 2011;46:1057-1064. 7. Miller LE, Lehtoranta L, Lehtinen MJ. The Effect of Bifidobacterium animalis ssp. lactis HN019 on cellular immune function in healthy elderly subjects: systematic review and meta-analysis. Nutrients. 2017;9:191.
1. Gopal PK, Prasad J, Gill HS Effects of the consumption of Bifidobacterium lactis HN019 (DR10 TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutrition Research. 2003;23:1313-1328. 2. Prasad J, Sazawal S, Dhingra U, Gopal PK Detection of viable Bifidobacterium lactis HN019 (DR10TM) in stools of children during a synbiotic dietary intervention trial. Intl Dairy J. 2013;30:64-67. 3. Wickens K, Black PN, Stanley TV, et al. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clinical Immunology. 2008;122:788-794. 4. Dalziel JE, Anderson RC, Peters JS, et al. Promotility action of the probiotic Bifidobacterium lactis HN019 extract compared with prucalopride in isolated rat large intestine. Frontiers in Neuroscience. 2017; 11. 5. Ibarra A, Latreille-Barbier M, Donazzolo Y, Pelletier X, Ouwehand AC. Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled and dose-ranging trial. Gut Microbes. 2017; Dec 11:0. 6. Waller PA, Gopal PK, Leyer GJ, et al. Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults. Scandinavian J Gastroenterology. 2011;46:1057-1064. 7. Miller LE, Lehtoranta L, Lehtinen MJ. The Effect of Bifidobacterium animalis ssp. lactis HN019 on cellular immune function in healthy elderly subjects: systematic review and meta-analysis. Nutrients. 2017;9:191.
