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HOWARU® Protect Prenatal+

HOWARU® Protect Prenatal+

HOWARU® Protect Prenatal+

Improve women’s immunity and vaginal health

“1000 days in their early life” is defined by the World Health Organization (WHO) as a “window of opportunity” for a person’s growth and development, which refers to the 280-day fetal period and 720 days after birth. In the first 1000 days of life, parental nutrition intake is closely related to the child’s health, which not only determines the baby’s growth, cognitive ability, but also has a profound impact on the development of the fetus and the immune system after birth. It has been shown in human clinical studies that both mothers and their babies benefit from probiotic dietary supplementation during pregnancy, birth and beyond.

HOWARU® Protect Prenatal+ is DuPont’s new probiotics product specially for women’s health. Containing L. acidophilus La-14® and L. rhamnosus HN001™, it can support the immune system health of mothers and their babies, make mothers happier and calmer, and help to maintain healthy vaginal microbiota and pH. In addition, it is proved safe and well tolerated.

Immune System Benefits for the Pregnant Mother and Fetus

A Probiotics in Pregnancy Study demonstrated Lactobacillus rhamnosus HN001™ supports the development of immune system health of infants and children by significantly reducing the prevalence of eczema and allergic sensitization compared to the placebo after 2, 4, and 6 years (for further information see HOWARU® Protect Earlylife).

Helps Reduce the Occurrence of Gestational Diabetes Mellitus (GDM)

Gestational diabetes mellitus (GDM) is a common disease during pregnancy. The results of mothers in The Probiotics in Pregnancy Study indicate that there were significant differences between the Lactobacillus rhamnosus HN001™ group and placebo group. Daily consumption of probiotics is associated with a lower prevalence of GDM.

Helps Reduce PND and Anxiety

Some new mothers are troubled by postnatal depression (PND), which will affect their ability to care for her new infant and her quality of life. Mothers in The Probiotics in Pregnancy Study were invited to fill out a questionnaire that considered their psychological well-being at 1-2 months after birth. The treatment group reported significantly lower depression and anxiety scores than those in the placebo group.

Helps Balance Vaginal Microbiota

Between 10% and 30% of women will experience bacterial vaginosis (BV) during pregnancy, which is a common cause of genital discomfort in women. Bacterial vaginosis is usually treated by metronidazole and clindamycin. However, the recurrence rate is high, because anti-biotics treatment will inhibit equally all microorganisms including normal and beneficial lactobacillus.

Lactobacillus is the main flora in the vagina of healthy women. The number of lactobacilli in the vagina of women with BV is significantly lower than that in healthy women.

A study demonstrated that L. acidophilus La-14™ and L. rhamnosus HN001™ can colonize the vagina for at least 1 week, following 14 days of oral ingestion of HOWARU® Protect Prenatal+ (L. acidophilus La-14®, L. rhamnosus HN001™, bovine lactoferrin), compared to the placebo group. Another human clinical study showed that HOWARU® Protect Prenatal+ is correlated with the restoration of moderate vaginosis and an improvement in symptoms of abnormal vaginal microbiota, compared to the placebo group.

Why Choose HOWARU® Protect Prenatal +?

  • Supports the immune health of expectant mothers and infants
  • Promotes mother’s happiness and calmness
  • Helps maintain a healthy vaginal microbiota and pH
  • Increases the number of beneficial bacteria
  • Proved safe and well tolerated
References 1. Barthow C et al., (2016) BMC Pregnancy Childbirth 16,133 2. Wickens KL et al., (2008) J Allergy Clin Immuno 122:788-794; (2012) Clin Exp Allergy 42 1071-1079; (2013) Clin Exp Allergy 43(9):1048-1057 3. Slykerman RF et al., (2017) Ebio Medicine Available at: http://doi. org/10/1016jebiom.2017.9.013 4. Wickens KL et al (2017) British Journal of Clinical Nutrition 17:804-813 5. De Alberti D et al., (2015) Arch Gynecol Obstet 292(4):861-867 6. Russo R et al., (2018) Arch Gynecol Obstet 298 (1):138-145