HOWARU® Bifido - Bif. lactis HN019
Human clinical studies
Safety
Dekker JW, Wickens K, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Tannock GW, Purdie G and Julian Crane. 2009. Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0–2 years. International Dairy Journal 19 (2009) 149–154.
Immune system enhancement
Arunachalam K, Gill HS, Chandra RK. 2000. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr 54:263-267.
Chiang BL, Sheih YH, Wang LH, Liao CK, Gill HS. 2000. Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur J Clin Nutr 54:849-855.
Gill HS, Rutherfurd KJ, Cross ML. 2001. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. Journal of Clinical Immunology 21:264-271.
Gill H, Rutherfurd KJ, Cross ML, Gopal PK. 2001. Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr 74:833-839.
Prescott SL, Wickens K, Westcott L, Jung W, Currie H, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Siebers R, Wu L, Crane J; Probiotic Study Group. 2008. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-c and breast milk transforming growth factor-b and immunoglobin A detection. Clin Exp Allergy Oct; 38(10):1606-14.
Wellness/Nutritional Status
Sazawal S, Dhingra U, Sarkar A, Dhingra P, Deb S, Marwah D, Menon VP, Kumar J, Black RE. 2004. Efficacy of milk fortified with a probiotic Bifidobacterium lactis (DR10™) and prebiotic galacto-oligosaccharides in prevention of morbidity and on nutritional status. Asia Pac J Clin Nutr (13):S28.
Atopic Dermatitis/Eczema
Sistek D, Kelly R, Wickens K, Stanley T, Fitzharris P, Crane J. 2006. Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clinical and Experimental Allergy 36:629-633.
Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J Probiotic Study Group. 2008. A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo controlled trial. J Allergy Clin Immunol 122(4):788-94.
Gastrointestinal Ecology
Gopal P, Prasad J, Gill HS. 2003. Effects of the consumption of Bifidobacterium lactis HN019 (DR10™) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects. Nutr Res 23: 1313-1328.
Ahmed M, Prasad J, Gill HS, Stevenson L, Gopal PK. 2007. Impact of consumption of different levels of Bifidobacterium lactis HN019 on the intestinal microflora of elderly human subjects. J Nutr 11(1):26-31.
Reviews
Gill HS. 1999. Potential of using dietary lactic acid bacteria for enhancement of immunity. Dialogue 32:6-11.
Gill HS, Darragh AJ, Cross ML. 2001. Optimizing immunity and gut function in the elderly. The Journal of Nutrition, Health and Aging 5(2):80-91.
Ouwehand AC, Philipp S. 2004. Bifidobacterium lactis HN019; the good taste of health. Agrofood Ind Hi-Tech 15:10-12.
Gopal P, Dekker J, Prasad J, Pillidge C, Delabre M, and M Collett. 2005. Development and commercialisation of Fonterra’s probiotic strains. Australian Journal of Dairy Technology 60:173-182.
Sanders ME. 2006. Summary of probiotic activities of Bifidobacterium lactis HN019. J Clin Gastroenterol 40:776-783.
Dekker J, Collett M, Prasad J, Gopal P. 2007. Functionality of Probiotics – Potential for Product Development. in Tai ES, Gillies PJ (eds): Nutrigenomics - Opportunities in Asia. Forum Nutr. Basel, Karger, vol. 60, pp 196-208.
Gill H, Prasad J. 2008. Probiotics, immunomodulation, and health benefits. Advances in Experimental Medicine and Biology 606:423-454.
Ouwehand AC, Lahtinen S, Nurminen P. 2009. Lactobacillus rhamnosus HN001 and Bifidobacterium lactis HN019. Handbook of probiotics and prebiotics. Lee YK & Salminen S. (eds.) John Wiley & Sons.
Lahtinen SJ, Kumar R. 2009. Probiotics improve immune system function. Indian Dairyman 61(4):49-54.
Information contained in this publication is based on Danisco's own research and development work and is to the best of Danisco's knowledge reliable. Users should, however, always conduct their own tests to determine the suitability for their own specific uses. Statements contained in this publication shall not be considered as a warranty of any kind, either expressed or implied. Danisco disclaims any liability for the infringement of any patents. Danisco's handling and storage instructions must be followed. Legislation regarding the use of the product may vary from country to country. The customer/user is responsible for ensuring compliance with local legislation and for obtaining all necessary certificates and authorizations. Copyright © 2004 Danisco. All rights reserved.
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