HOWARU® Rhamnosus - Lb. rhamnosus HN001
Human clinical studies
Safety
Dekker JW, Wickens K, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Tannock GW, Purdie G, and Julian Crane. 2009. Safety aspects of probiotic bacterial strains Lactobacillus rhamnosus HN001 and Bifidobacterium animalis subsp. lactis HN019 in human infants aged 0–2 years. International Dairy Journal 19 (2009) 149–154.
Immune system enhancement
Gill HS, Cross ML, Rutherfurd KJ, Gopal PK. 2001. Dietary probiotic supplementation to enhance cellular immunity in the elderly. British Journal of Biomedical Science 58:94-96.
Gill HS, Rutherfurd KJ, Cross ML. 2001. Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. Journal of Clinical Immunology 21:264-271.
Gill HS, Rutherfurd KJ. 2001. Probiotic supplementation to enhance natural immunity in the elderly: effects of a newly characterized immunostimulatory strain Lactobacillus rhamnosus HN001 (DR20™) on leucocyte phagocytosis. Nutrition Research 21:183-189.
Sheih YH, Chiang BL, Wang LH, Liao C, Gill HS. 2001. Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. Journal of the American College of Nutrition 20:149-156.
Prescott SL, Wickens K, Westcott L, Jung W, Currie H, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Siebers R, Wu L, Crane J; Probiotic Study Group. 2008. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-c and breast milk transforming growth factor-b and immunoglobin A detection. Clin Exp Allergy 2008 Oct; 38(10):1606-14.
Atopic Dermatitis/Eczema
Sistek D, Kelly R, Wickens K, Stanley T, Fitzharris P, Crane J. 2006. Is the effect of probiotics on atopic dermatitis confined to food sensitized children? Clinical and Experimental Allergy 36:629-633.
Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J: Probiotic Study Group. 2008. A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo controlled trial. J Allery Clin Immunol 122(4):788-94.
Gastrointestinal Ecology
Tannock GW, Munro K, Harmsen HJM, Welling GW, Smart J, Gopal PK. 2000. Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20™. Applied and Environmental Microbiology 66:2578-2588.
Walter J, Hertel C, Tannock GW, Lis CM, Munro K, Hammes WP. 2001. Detection of Lactobacillus, Pediococcus, Leuconostoc, and Weissella species in human feces by using group-specific PCR primers and denaturing gradient gel electrophoresis. Applied and Environmental Microbiology 67(6):2578-2585.
Reviews
Gill HS. 1998. Stimulation of the immune system by lactic cultures. International Dairy Journal 8:535-544.
Gill HS. 1999. Potential of using dietary lactic acid bacteria for enhancement of immunity. Dialogue 32:6-11.
Gill HS, Darragh AJ, Cross ML. 2001. Optimizing immunity and gut function in the elderly. The Journal of Nutrition, Health and Aging 5(2):80-91.
Gopal P, Dekker J, Prasad J, Pillidge C, Delabre M, and M Collett. 2005. Development and commercialisation of Fonterra’s probiotic strains. Australian Journal of Dairy Technology 60:173-182.
Dekker J, Collett M, Prasad J, Gopal P. 2007. Functionality of Probiotics – Potential for Product Development. in Tai ES, Gillies PJ (eds): Nutrigenomics - Opportunities in Asia. Forum Nutr. Basel, Karger, vol. 60, pp 196-208.
Gill H, Prasad J. 2008. Probiotics, immunomodulation, and health benefits. Advances in Experimental Medicine and Biology 606:423-454.
Ouwehand AC, Lahtinen S. and Nurminen P. 2009. Lactobacillus rhamnosus HN001 and Bifidobacterium lactis HN019. Handbook of probiotics and prebiotics. Lee, Y.K. & Salminen, S. (eds.) John Wiley & Sons.
Lahtinen SJ, Kumar R. 2009. Probiotics improve immune system function. Indian Dairyman 61(4):49-54.
Information contained in this publication is based on Danisco's own research and development work and is to the best of Danisco's knowledge reliable. Users should, however, always conduct their own tests to determine the suitability for their own specific uses. Statements contained in this publication shall not be considered as a warranty of any kind, either expressed or implied. Danisco disclaims any liability for the infringement of any patents. Danisco's handling and storage instructions must be followed. Legislation regarding the use of the product may vary from country to country. The customer/user is responsible for ensuring compliance with local legislation and for obtaining all necessary certificates and authorizations. Copyright © 2004 Danisco. All rights reserved.
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