Lacticaseibacillus paracasei Lpc-37® improves psychological and physiological markers of stress and anxiety in healthy adults: a randomized, double-blind, placebo-controlled and parallel clinical trial (the Sisu study)¹

Study aim 

To assess the effect of Lacticaseibacillus paracasei Lpc-37®, previously known as Lactobacillus paracasei Lpc-37®, on stress and anxiety.

Study design

Randomized, double-blind, placebo-controlled, single-site study, with a 5-week intervention

Study method

• 120 healthy volunteers 18 to 45 years of age were randomized into 2 groups
  • Placebo: microcrystalline cellulose, magnesium stearate, silicon dioxide
  • Verum: Lacticaseibacillus paracasei Lpc-37® (17.5 billion CFU/day), microcrystalline cellulose, magnesium stearate, silicon dioxide
• The Trier Social Stress Test (TSST) was administered at the end of the study as a challenge triggering perceived and physiological stress responses
• The psychological and physiological responses to the TSST, a general psychometric assessment including validated questionnaires, inventories, and self-report scales, including the Perceived Stress Scale to measure stress and mood and a more general continuous assessment of sleep, and overall well-being were measured in the study

Study results

Lpc-37® helped to significantly manage the psychological response to stress¹

Change in peceived stress score from baseline to end of study

The Lpc-37® group reported significantly less perceived stress compared with the placebo group after 5 weeks  (P=0.048)

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