A systematic review and meta-analysis of 4 clinical trials to determine the efficacy of B. animalis ssp. lactis HN019™ supplementation on cellular immune activity in healthy elderly subjects.
Systematic review was conducted by searching databases for clinical trials on phagocytic capacity or natural killer cell activity following HN019™ use in the elderly.
- Random effects meta-analysis was performed with standardized mean difference (SMD) and 95% confidence interval between probiotic and control groups for each outcome
- Meta-analysis of four clinical studies in healthy elderly adults showed that HN019™ is associated with improved phagocytic capacity and natural killer cell activity compared to controls (P<0.001 and P=0.02, respectively)
1. Miller LE, Lehtoranta L, Lehtinen MJ. The effect of Bifidobacterium animalis ssp. lactis HN019 on cellular immune function in healthy elderly subjects: systematic review and meta-analysis. Nutrients. 2017; 9(3):191.